Publications


† First/Co-first author(s), * Corresponding/Co-corresponding author(s)


Articles

  1. Strawbridge, S.E.†*, Schrattel, A.K., Humphreys, P., Jones, K.A., Artus, J., Hadjantonakis, A.K., Fletcher, A.G.*, Nichols, J.* (2025). Donor embryonic stem cells displace host cells of 8-cell-stage chimeras to the extra-embryonic lineages by spatial crowding and FGF4 signalling. Development, 152 (12), dev204518.
  2. Chinnaiya, K.†, Groves, I., Manning, E., Place, E., Furley, C., Strawbridge, S.E., Fletcher, A.G., Placzek, M.* (2025). Balancing SHH and BMP/FGF10 to specify tuberal hypothalamic neurons and glia. Developmental Biology.
  3. Strawbridge, S.E.†*, Kurowski, A., Corujo-Simón, E., Fletcher, A.N., Nichols, J.*, Fletcher, A.G.* (2023). insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology. Biology Open, 12 (9), bio060055.
  4. Bergmann, S.†, Penfold, C.A.†, Slatery, E.†, Siriwardena, D., Drummer, C., Clark, S., Strawbridge, S.E., Kishimoto, K., Vickers, A., Tewary, M., Kohler, T.N., Hollfelder, F., Reik, W., Sasaki, E., Behr, R., Boroviak, T.E.*(2022). Spatial profiling of early primate gastrulation in utero. Nature, 609 (7925), 136-143.
  5. Guo, G.†, Stirparo, G.G.†, Strawbridge, S.E.†, Spindlow, D., Yang, J., Clarke, J., Dattani, A., Yanagida, A., Li, M.A., Myers, S., Özel, B.N., Nichols, J.*, Smith, A.* (2021). Human naïve epiblast cells possess unrestricted lineage potential. Cell Stem Cell, 28 (6), 1040-1056.
  6. Stirparo, G.G.†, Kurowski, A.†, Yanagida, A., Bates, L.E., Strawbridge, S.E., Hladkou, S., Stuart, H.T., Boroviak, T.E., Silva, J.C.R., Nichols, J.* (2021). OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms. PNAS, 118 (3), e2008890118.


Book Chapters

  1. Steindel, M.†, Orsine de Almeida, I., Strawbridge, S., Chernova, V., Holcman, D., Ponjavic, A.*, Basu, S.* (2022). Studying the dynamics of chromatin-binding proteins in mammalian cells using single-molecule localization microscopy. In Chromosome Architecture: Methods and Protocols, pp. 209-247. Springer US.
  2. Strawbridge, S.E.†, Clarke, J., Guo, G., Nichols, J.* (2021). Deriving human naïve embryonic stem cell lines from donated supernumerary embryos using physical distancing and signal inhibition. In Human Naïve Pluripotent Stem Cells, pp. 1-12. Springer US.


Preprints

  1. Strawbridge, S.E.†*, Bates, L.E.†, Ross, C., Jones, K.A., Azami, T., Lohoff, T., Paramor, M., Murray, V., Cidral, A.L., Clarke, J., Rostovskaya, M., Guo, G., Nichols, J.* (2025). A new resource of clonal pluripotent human stem cell lines exhibiting inter- and intra-embryo consistency and variability. bioRxiv.
  2. Steindel, M.†, Davis, O.†, Neumann, K., Pirvan, L., Agsu, G., Kranz, A., Adhya, D., Morf, J., Yang, S., Zhang, Z., Fu, J., Barile, M., Wurmser, A., Strawbridge, S., Mohorianu, I., Madapura, P., Huntly, B., Göttgens, B., Holcman, D., Samarajiwa, S., Klenerman, D., Anastassiadis, K., Stewart, A.F.*, Basu, S.* (2025). A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation. bioRxiv.
  3. Strawbridge, S.E.†, Blanchard, G.B., Smith, A.*, Kugler, H.*, Martello, G.* (2020). Embryonic stem cells commit to differentiation by symmetric divisions following a variable lag period. bioRxiv.


Dissertations

  1. English, H.L. (2025). Decoding Early Human Development: A Pipeline for Exploring How Genetic Variation Shapes Lineage Allocation. MSc Reproductive and Developmental Medicine, University of Sheffield.
  2. Higgins-Aguilar, S.J. (2025). Investigating Early Pregnancy Loss Using Human Pluripotent Stem Cells to Model Placental Tissues. MSc Reproductive and Developmental Medicine, University of Sheffield.
  3. Guma'a, K. (2024). Spatiotemporal analysis of NANOG chromatin-binding dynamics in mouse embryonic stem cells. MPhil Biochemistry, University of Cambridge.
  4. Preston, A. (2024). Investigating effects of nanoscale transport mechanisms on the formation of the FGF4 morphogen gradient during early mouse development. MSc Systems Biology, University of Cambridge.
  5. Bowers, K. (2023). A data-driven nuclear scale coarse-grained spatiotemporal model of transcription factor kinetics within pluripotent cells. MPhil Computational Biology, University of Cambridge.
  6. Yuze, C. (2023). Transcription factor condensate formation under homotypic interactions is concentration and valency-dependent. MSc Systems Biology, University of Cambridge.
  7. Berger, S. (2022). Establishing a nuclear scale coarse-grained model of transcription factor condensate formation within a physiological context. MPhil Biological Sciences (Stem Cell Biology), University of Cambridge.
  8. Chernova, V. (2021). Multi-scale cluster identification in single molecule localization microscopy data using persistent homology. MSc Systems Biology, University of Cambridge.
  9. Nikolényi, G. (2020). An analytical framework for quantifying spatial clustering of transcription factors from three-dimensional super-resolution microscopy data. MSc Systems Biology, University of Cambridge.
  10. Schrattle, A.K. (2019). Investigating specification and regulation of the extraembryonic lineages during early mouse development. BSc Engineering, IMC University of Applied Sciences Krems.
  11. Strawbridge, S.E. (2019). Understanding the dynamics of embryonic stem cell differentiation. PhD Biochemistry, University of Cambridge.
  12. Strawbridge, S.E. (2013). The effects of fluid flow on cell aggregation: a hybrid approach to modeling chemotaxis. MSc Mathematical Modelling & Scientific Computing, University of Oxford.
  13. Strawbridge, S.E. (2011). Dissecting the relationship between SOD and GSH in HepG2 cells. BS Biochemistry, West Virginia University.
  14. Strawbridge, S.E. (2011). Examination of a Hamiltonian Kepler problem with classical and special relativistic mechanics. BS Mathematics, West Virginia University.